NANO CBD



What is Nano CBD?

CBD (cannabidiol) has taken the world after studies showing that it may help with pain, psychiatric disorders such as insomnia, depression, and anxiety. CBD is a chemical compound derived from leaves and flowers of the hemp plant. The recent advancement in the CBD industry is ‘Nano CBD.’ Nanotechnology is the study of structures at the supramolecular level. In medicine, the word nano refers to having the potential for improved nutrient delivery.


In CBD, this technology is utilized to improve its potency and efficacy. Nano refers to the intensification or enhancement of the CBD effects. It is a new form of hemp isolate in which terpenes are removed during the extraction process. This removal will give the purest form of CBD contrary to full-spectrum CBD, which contains terpenes. Nano CBD is also referred to as water-soluble CBD, or nano emulsified CBD. CBD is water-insoluble, but nano CBD is made water-soluble by a process known as emulsification. It makes Nano CBD more effective at lower doses than CBD.


Benefits Of Nano CBD

● Bioavailability

When full-spectrum CBD is administered, some part of it is lost while moving through the stomach, intestines, and liver because of larger size. Nano CBD, on the other hand, is absorbed efficiently, being microscopic-sized particles.


Less Dosage requirement

Nano CBD being smaller in size and improved in efficacy is required in a lesser dosage in comparison to CBD. It is absorbed entirely, so lower/lesser doses can produce the required effect.


● Early response

Nano CBD is absorbed efficiently and quickly, so it produces an immediate response in your body.


Water Solubility

Being water-soluble Nano CBD is absorbed more rapidly and increases its bioavailability.


How Nano CBD Works?

CBD molecule by nature is hydrophobic, which means that it does not mix with water, but it is lipophilic, which means that it can bind with lipids and fats. The human body has more content of water, so it’ll absorb hydrophilic substances easily and quickly. But CBD being hydrophobic cannot be absorbed efficiently, resulting in reduced bioavailability. Other than this reason for slow absorption, it is also broken down during the process of absorption in the intestines and liver. This metabolism minimizes the amount of available CBD. If CBD molecule is broken down into nanoparticles, scientists found that it behaves differently in terms of absorption. It becomes hydrophilic and is already lipophilic. Both these properties will eventually allow the nano CBD particles to get absorbed into the bloodstream more quickly. As the particles are too small, they are immediately absorbed, leaving no time to get metabolized. This nanotechnology makes CBD a massively better compound that is readily accepted and integrated into the body.


Research Evidence

There is a lot of ongoing clinical studies and research on Nano CBD, yet some research studies proved it to be an effective and beneficial compound. A study conducted to test the bioavailability and pharmacokinetics of CBD and Nano CBD. It showed that CBD undergoes extensive first-pass metabolism, resulting in reduced bioavailability. Nano CBD, on the other hand, has more availability because of being water-soluble.


A similar study conducted by scientists from Showa University, Tokyo, and Mahidol University, Bangkok. The results of this study were also published in the journal Medical Cannabis and Cannabinoids. The researchers first created Nano CBD (99% pure CBD powder, an oil phase, and distilled water). The absorption of Nano CBD is much faster as compared to CBD. Nano CBD reaches maximum concentration level in 2 and a half hours, while CBD takes 8 hours to reach maximum concentration level in blood. The research concluded that the bioavailability of CBD is 73%, while nano CBD is 94%. The other thing the researchers found in this study is that Nano CBD absorption is bile independent, while CBD relies on bile for absorption. It also indicates towards the speedy absorption of Nano CBD.


In a recent study conducted by Sante laboratories, Austin, Texas, also proved that nano CBD is the fastest and most efficient CBD formulation. This formulation allows the users to get most of the benefits with each and a lesser dose. Nanoparticles facilitate optimal absorption of CBD up to 80% producing effects at a rapid rate. It means that nano CBD has higher bioavailability and with more percentage of CBD.


A study published in 2018 in the journal of pharmaceutical sciences compared the absorption of Sativex (CBD) and Nano CBD. The study was performed on healthy male volunteers and showed an overall increased absorption of Nano CBD.


Uses of Nano CBD

CBD is in use for managing many medical conditions. Nano CBD is also beneficial for all such conditions where CBD is effective. The research may be one of the most effective compounds in the treatment of the following conditions.

● It may help to manage anxiety and stress without any side effects effectively. It works by reducing the body’s natural response to stress (release cortisol) and increases the levels of serotonin and anandamide.

● It may be used for chronic inflammatory conditions (arthritis) and pain.

● It is also may help to improve sleep cycles and patterns, which is affected due to stress or any psychiatric disorder.The benefit of Nano CBD is that it is not addictive or psychoactive. It is also required in lesser doses to get the desired results. Many companies are offering Nano CBD products claiming it to be effective. But one must do proper research before getting a Nano CBD product because many companies claim falsely. Nano CBD is an emerging compound, and it’ll have a promising future in the CBD industry.


The benefits are much, but there is still room for research and clinical studies to prove its efficacy and benefits. However, until now, nanoparticles are considered to be an effective asset to deliver cannabinoids to the target cells and tissues. Go to nanocbdplus.com to get your Nano CBD today!


References:

Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018).

Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478. doi:10.3390/molecules23102478


Cherniakov I, Izgelov D, Domb AJ, Hoffman A. (2017). The effect of Pro NanoLipospheres (PNL)

formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model. Eur J Pharm Sci. 2017 Nov 15;109:21-30. doi: 10.1016/j.ejps.2017.07.003. Epub 2017 Jul 20. DOI: 10.1016/j.ejps.2017.07.003


Juan Aparicio-Blanco, Víctor Sebastián, Jean P. Benoit, Ana I. Torres-Suárez. Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged-release carriers for glioma therapy: In vitro screening of critical parameters. European Journal of Pharmaceutics and Biopharmaceutics, Volume 134, 2019, Pages 126-137. https://doi.org/10.1016/j.ejpb.2018.11.020.


Millar, S. A., Stone, N. L., Yates, A. S., & O'Sullivan, S. E. (2018). A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in pharmacology, 9, 1365. doi:10.3389/fphar.2018.01365


Nakano Y, Tajima M, Sugiyama E, Sato V, H, Sato H (2019). Development of a Novel Nano­emulsion Formulation to Improve Intestinal Absorption of Cannabidiol. Med Cannabis Cannabinoids 2019;2:35-42. doi: 10.1159/000497361